Teicoplanin pharmacokinetics in intravenous drug abusers being treated for bacterial endocarditis
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منابع مشابه
Teicoplanin pharmacokinetics in intravenous drug abusers being treated for bacterial endocarditis.
The pharmacokinetics of teicoplanin were determined after multiple 30-min intravenous infusions of 10 to 15 mg/kg every 12 to 24 h in 11 intravenous drug abuse (IVDA) patients being treated for bacterial endocarditis. Multiple serum samples were obtained over 7 to 14 days. Twenty-four-hour urine collections were obtained on days 1 and 5. Serum concentration-time data were analyzed by using mult...
متن کامل[Infectious endocarditis in intravenous drug abusers].
Clinical course of infectious endocarditis (IE) was analysed for 43 intravenous drug abusers. 42 of them had primary IE, one patient--secondary. Acute course and high activity of the disease were registered in 86% of the patients. IE was provoked by Staphylococcus aureus (50%), Staphylococcus epidermidis 920%), Staphylococcus haemolyticus (11%), E. coli (8%), Pseudomonas aeruginosa (2%), Candid...
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The case reports of 186 intravenous drug abusers admitted over a three year period were studied. Nineteen had proven staphylococcal septicaemia. Echocardiography showed tricuspid vegetations in seven and aortic vegetations in two. Eighteen out of 19 had systolic murmurs, but only the two patients with aortic vegetations had diastolic murmurs. The chest x ray showed opacities in 10 patients (all...
متن کاملVancomycin pharmacokinetics in burn patients and intravenous drug abusers.
The pharmacokinetics of vancomycin were evaluated in 34 patients (10 burn patients, 14 intravenous drug abusers [IVDA], and 10 controls). Multiple serum samples were drawn following a 1-h vancomycin infusion at steady state over an 8- to 12-h dosing interval. Pharmacokinetic parameters were derived by noncompartmental analysis. There were no significant differences among the groups with respect...
متن کاملMixed bacterial endocarditis in an intravenous drug misuser.
Sir, Bacterial endocarditis is a frequent complication of intravenous (i.v.) drug misuse often associated with a significant mortality and morbidity. Staphylococcus aureus is the commonest infecting organism, usually presenting as a 'pneumonia' or septicaemia and with no or minimal cardiac murmurs.1 However, other pathogens, especially skin derived streptococci, are important and serious causes...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1991
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.35.4.696